Chemistry Experience

AvTech Labs – this is where I started my career as a Chemist (yep, a chemistry geek).

In the lab – I was focused on method development (what those of us in the lab did that is most like what web/software coders do when they iterate on code – our lines of code were experimental methods).  Most all of my methods supported large scale pharmacokinetic studies being conducted by our F500 clients – Pharmacia & Upjohn (now Pfizer), Parke Davis (now Pfizer) and Eli-Lilly.  I did a ton of work on Upjohn’s Zyvox ( now a $2o0M/yr antibiotic) on its way to New Drug Approval by the FDA and worked on a cool project to determine and quantify a Parke Davis research compound, CI-1017.  Very rewarding and great learning experience working at a startup but helping get big time products to market.

Name in print – while in the lab I co-authored a few scientific posters/papers for national conferences.

• DETERMINATION OF CI-1017 AND ITS N-OXIDE METABOLITE (PD 159113) IN HUMAN PLASMA BY LC/MS/MS, 1998 AAPS Annual Meeting.
• Determination of linezolid (PNU-100766) in human plasma g isocratic HPLC-MS-MS with liquid-liquid extraction (AvTech Laboratories, Inc.). In Proceedings of the Tenth International Symposium on Pharmaceutical and Biomedical Analysis, 1999.
• The methods that my colleagues and I developed are also referenced in a few prestigious applied science journals.
  • Impact of ontogeny on linezolid disposition in neonates and infants^,, Clinical Pharmacology & Therapeutics (2003) 74, 413–422
  • Single dose pharmacokinetics of linezolid in infants and children, The Pediatric Infectious Disease Journal:Volume 19(12)December 2000pp 1178-1184

• And one of my favorite experiences was successfully assaying microgram quantities of drug in pediatric CSF with the CEO of major pharma company waiting on results.  talk about pressure…